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Published on: June 21, 2024
Chronic nausea and vomiting: evaluation and treatment.
Brian E Lacy1, Henry P Parkman1, Michael Camilleri1
1Mayo Clinic, Jacksonville, FL, USA. Temple University, Philadelphia, PA, USA. Mayo Clinic, Rochester, MN, USA.
Chronic nausea and vomiting (CNV) are complex conditions lasting over four weeks, stemming from various gastrointestinal and non-gastrointestinal issues. Effective management requires careful evaluation and personalized treatment strategies.
Area of Science:
- Gastroenterology
- Internal Medicine
Background:
- Chronic nausea and vomiting (CNV) are defined as symptoms lasting 4 weeks or more.
- These conditions arise from diverse gastrointestinal and non-gastrointestinal pathophysiological processes.
- The economic and quality-of-life impacts of CNV are significant, though prevalence data are limited.
Purpose of the Study:
- To review the evaluation and treatment of patients experiencing chronic nausea and vomiting.
- To emphasize common gastrointestinal causes of CNV.
Main Methods:
- Initial diagnostic evaluation distinguishes between gastrointestinal and non-gastrointestinal etiologies.
- Gastrointestinal causes are categorized based on gastric emptying studies (delayed vs. normal).
- Exclusion of anatomic, mechanical, and biochemical factors is crucial.
Main Results:
- Gastroparesis and cyclic vomiting syndrome are examples of specific GI conditions contributing to CNV.
- Non-gastrointestinal causes include medications, vestibular, and neurologic disorders.
- A validated treatment algorithm for CNV is currently lacking.
Conclusions:
- Treatment for CNV should be individualized, considering benefits, side effects, and costs.
- Comprehensive evaluation is key to identifying the underlying cause of chronic nausea and vomiting.
- Further research may lead to standardized treatment protocols for CNV.
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Pathophysiology of Vomiting
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...

