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Diabetes and Hypertension: Clinical Update
Darshan Khangura1,2, L Romayne Kurukulasuriya1,2, Adam Whaley-Connell1,2,3,4,5
1School of Medicine, Diabetes and Cardiovascular Center, University of Missouri-Columbia, Columbia, Missouri, USA.
American Journal of Hypertension
|March 17, 2018
Summary
Managing hypertension in type 2 diabetes is crucial for reducing cardiovascular risks. Newer hypoglycemic agents offer complementary blood pressure reduction and improved cardiovascular outcomes in this high-risk group.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Background:
- Hypertension in type 2 diabetes significantly increases cardiovascular morbidity and mortality.
- Current hypertension management strategies and targets are under continuous review, with ongoing debate regarding optimal blood pressure goals for diabetic patients.
- Despite awareness and treatment, a considerable residual risk for cardiovascular events persists in hypertensive individuals with diabetes.
Purpose of the Study:
- To explore complementary blood pressure reduction strategies for hypertensive individuals with type 2 diabetes.
- To highlight the role of newer hypoglycemic agents in managing cardiovascular risk in this population.
Main Methods:
- Review of large-scale clinical trials investigating cardiovascular outcomes.
- Analysis of data on the blood pressure lowering effects of specific hypoglycemic agents.
Main Results:
- Sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists have demonstrated favorable cardiovascular outcomes.
- These hypoglycemic agents can complement traditional antihypertensive therapies in reducing blood pressure.
- Consideration of these agents is beneficial for additional glycemic control and cardiovascular risk reduction.
Conclusions:
- Newer hypoglycemic agents offer a dual benefit of glycemic control and blood pressure reduction in patients with type 2 diabetes and hypertension.
- These agents represent a valuable addition to the management of cardiovascular risk in this high-risk population.
- Integrating the blood pressure-lowering effects of these agents into treatment plans is recommended.
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