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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
Published on: April 21, 2012
Cutaneous Barriers and Skin Immunity: Differentiating A Connected Network
Stefanie Eyerich1, Kilian Eyerich2, Claudia Traidl-Hoffmann3
1ZAUM - Center of Allergy and Environment, Technical University and Helmholtz Center Munich, Munich, Germany.
Abstract:
The skin is the outermost barrier of the organism that ensures protection from external harm. Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ that can sense danger signals and mount perfectly adapted defense measures in response to invading pathogens. This Review highlights the different levels of the cutaneous barrier (the microbiome, chemical, physical, and immune barriers), their characteristics, and functional, highly interconnected network of cells and mediators that allow balanced defense measures to protect the body and maintain barrier integrity.
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