Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

132.4K
Overview
132.4K
Protein Networks02:26

Protein Networks

4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Humoral Immune Responses01:36

Humoral Immune Responses

84.1K
Overview
84.1K
Dietary Connections01:23

Dietary Connections

62.2K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
62.2K
Physiological Barriers01:25

Physiological Barriers

5.3K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

European consensus recommendations for nummular eczema: A modified Delphi study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Addiction in chronic inflammatory skin diseases: A systematic review of prevalence, impact and screening practices.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

EAACI Guidelines on Environmental Science for Allergy and Asthma-Evidence-Based Recommendations for Prevention and Public Health Action to Mitigate the Impact of Pollen Exposure on Respiratory Allergy.

Allergy·2026
Same author

ASPRV1<sup>R208M</sup> in a patient with a nonsyndromic epidermal differentiation disorder/ichthyosis.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Benefit-risk profile comparison between dupilumab and upadacitinib: a structured benefit-risk assessment of the Heads Up trial.

The Journal of dermatological treatment·2026
Same author

From legacy subsets to auditable descriptors: implementing the 2025 T-cell nomenclature guidelines for inflammatory skin diseases.

The British journal of dermatology·2026

Related Experiment Video

Updated: Feb 13, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

22.6K

Cutaneous Barriers and Skin Immunity: Differentiating A Connected Network.

Stefanie Eyerich1, Kilian Eyerich2, Claudia Traidl-Hoffmann3

  • 1ZAUM - Center of Allergy and Environment, Technical University and Helmholtz Center Munich, Munich, Germany.

Trends in Immunology
|March 20, 2018
PubMed
Summary

The skin acts as a dynamic barrier, not just a physical shield. It actively senses threats and deploys defense mechanisms to protect the body and maintain integrity.

More Related Videos

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

11.5K
Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

10.6K

Related Experiment Videos

Last Updated: Feb 13, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

22.6K
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

11.5K
Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

10.6K

Area of Science:

  • Immunology
  • Dermatology
  • Microbiology

Background:

  • The skin serves as the body's primary defense against external harm.
  • Recent research reveals the skin as an active sensory organ capable of responding to pathogens.

Purpose of the Study:

  • To review the multifaceted nature of the cutaneous barrier.
  • To explore the interconnectedness of the skin's defense systems.

Main Methods:

  • Literature review of current research on skin barrier function.
  • Synthesis of information on the microbiome, chemical, physical, and immune barriers.

Main Results:

  • The skin comprises multiple integrated barrier levels: microbiome, chemical, physical, and immune.
  • These barriers function through a complex network of cells and mediators.
  • This network enables balanced defense and maintains barrier integrity.

Conclusions:

  • The skin is a sophisticated, active organ with layered defense mechanisms.
  • Understanding these interconnected barriers is crucial for maintaining overall health and protection.