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Updated: Feb 13, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
Published on: May 1, 2019
Function of tumor necrosis factor alpha before and after mutation in gastric cancer
Xia Zhang1, Jianjun Wang2, Huanzhang Shao1
1Intensive Care Unit, Henan Provincial People's Hospital, Zhengzhou 450000, PR China.
Purpose:
To explore the cause of functional changes of tumor necrosis factor alpha (TNF-α) in development of gastric cancer through the structural changes of each site in TNF-α before and after mutation.
Methods:
Three typical mutant sites (TNF-α-308G/A, 857C/T and 863C/A of TNF-α) were chosen and methods like ab initio modeling was adopted for 3D modeling of TNF-α before and after mutation, besides, the structural changes were also analyzed.
Results:
Mutation of TNF-α-308G/A led to the production of multiple helical structures and that of 863C/A caused the production of one helical structure in its adjacent region. Mutation of 857C/T, however, did not cause the change in the basic structure of TNF-α.
Conclusions:
Structural changes of TNF-α may have a significant effect on development of gastric cancer.
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