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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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High throughput detection chain for time domain optical mammography.

Edoardo Ferocino1, Edoardo Martinenghi1, Alberto Dalla Mora1

  • 1Politecnico di Milano, Department of Physics, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.

Biomedical Optics Express
|March 20, 2018
PubMed
Summary

A new Silicon Photomultiplier detection chain enhances optical mammography signal levels and efficiency. This robust, cost-effective system offers improved performance for clinical applications.

Keywords:
(030.5260) Photon counting(040.6070) Solid state detectors(170.3830) Mammography(170.5280) Photon migration(170.6510) Spectroscopy, tissue diagnostics(170.6920) Time-resolved imaging

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Area of Science:

  • Biomedical Optics
  • Medical Imaging Technology

Background:

  • Time domain optical mammography requires sensitive detection systems for accurate breast tissue analysis.
  • Previous systems using photomultiplier tubes had limitations in signal level and count rate.

Purpose of the Study:

  • To develop and evaluate a novel detection chain for multi-wavelength optical mammography.
  • To improve signal detection efficiency and count rate capabilities.

Main Methods:

  • A new detection chain was designed using 8 Silicon Photomultipliers and a time-to-digital converter.
  • Performance was assessed using BIP and MEDPHOT protocols across 635-1060 nm wavelengths.

Main Results:

  • Photon detection efficiency improved by up to 3 orders of magnitude.
  • Maximum count rate increased by a factor of 10 compared to previous systems.
  • Optical parameter estimation performance is comparable to established systems.

Conclusions:

  • The novel Silicon Photomultiplier detection chain offers significant improvements in efficiency and count rate.
  • The system provides a robust, cost-effective solution for clinical optical mammography.
  • This technology advances signal detection for improved breast cancer diagnostics.