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Updated: Feb 13, 2026

Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation
Published on: August 1, 2010
The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate
Peng Wei1, Katja K Dove1, Claire Bensard1
1Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
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Compared to their differentiated progeny, stem cells are often characterized by distinct metabolic landscapes that emphasize anaerobic glycolysis and a lower fraction of mitochondrial carbohydrate oxidation. Until recently, the metabolic program of stem cells had been thought to be a byproduct of the environment, rather than an intrinsic feature determined by the cell itself. However, new studies highlight the impact of metabolic behavior on the maintenance and function of intestinal stem cells and hair follicle stem cells. This Review summarizes and discusses the evidence that metabolism is not a mere consequence of, but rather influential on stem cell fate.
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