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Updated: Feb 13, 2026

Imaging Dendritic Spines in Caenorhabditis elegans
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Pin1 mediates Aβ42-induced dendritic spine loss

Nancy R Stallings1, Melissa A O'Neal1, Jie Hu1

  • 1Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

Science Signaling
|March 22, 2018
PubMed
Summary

Early Alzheimer's disease involves dendritic spine loss, driven by amyloid-beta signaling. The protein Pin1 is crucial for maintaining dendritic spines and preventing synaptic loss in this neurodegenerative condition.

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