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Bleeding patterns for the Liletta® levonorgestrel 52 mg intrauterine system
Courtney A Schreiber1, Stephanie B Teal2, Paul D Blumenthal3
1a Department of Obstetrics and Gynecology , University of Pennsylvania , Philadelphia , PA , USA.
Summary
The Liletta levonorgestrel 52 mg intrauterine system (IUS) leads to increased amenorrhea and infrequent bleeding over time. Bleeding patterns are consistent across different women, with few discontinuations due to bleeding concerns.
Area of Science:
- Reproductive Health
- Contraception
- Gynecology
Background:
- The levonorgestrel 52 mg intrauterine system (IUS) is a contraceptive option.
- Understanding bleeding patterns is crucial for user satisfaction and continuation rates.
Purpose of the Study:
- To evaluate bleeding patterns for the Liletta levonorgestrel 52 mg IUS.
- To assess amenorrhea rates and bleeding characteristics using World Health Organization Belsey definitions.
Main Methods:
- A prospective multicenter trial involving 1700 women.
- Daily diaries for 2 years, followed by questionnaires.
- Analysis of bleeding patterns (amenorrhea, infrequent, frequent, prolonged, irregular) over 3 years.
Main Results:
- Amenorrhea rates reached 19% at 1 year and 37% at 3 years.
- Infrequent bleeding increased to 30% by Year 1 and remained stable.
- Frequent, prolonged, and irregular bleeding decreased significantly; discontinuation for bleeding was uncommon (2.1%).
Conclusions:
- Amenorrhea and infrequent bleeding increase with Liletta IUS use over time.
- Bleeding patterns showed no significant differences based on parity or obesity.
- Discontinuation due to bleeding concerns is rare with the Liletta 52 mg IUS.
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