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Sleep EEG of Microcephaly in Zika Outbreak
Paulo Afonso Medeiros Kanda1, Aline de Almeida Xavier Aguiar2, Jose Lucivan Miranda3
1a Neurovale EEG Laboratory , Taubaté , São Paulo , Brazil.
The Neurodiagnostic Journal
|March 23, 2018
Summary
Electroencephalogram (EEG) findings in epileptic children with microcephaly (MC) linked to Zika virus (ZIKV) revealed distinct patterns. These EEG results highlight the importance of neuroimaging in diagnosing congenital MC, especially during ZIKV outbreaks.
Area of Science:
- Neurology
- Virology
- Pediatrics
Background:
- Microcephaly (MC) is a global health concern, particularly following the 2015 Zika virus (ZIKV) pandemic.
- Congenital MC can result from various infections and perinatal complications.
Purpose of the Study:
- To describe electroencephalogram (EEG) findings in epileptic children with congenital microcephaly.
- To investigate potential associations between specific EEG patterns and etiological factors, including ZIKV infection.
Main Methods:
- Retrospective review of sleep EEG recordings from 23 epileptic children with microcephaly.
- Analysis of clinical data, including maternal serology for infectious agents and perinatal history.
Main Results:
- Diffuse slowing and hypsarrhythmia were common background EEG abnormalities.
- A distinct EEG pattern of frontocentrotemporal rhythmic activity was observed in some cases, including those associated with ZIKV.
- In ZIKV cases, this rhythmic activity co-occurred with hypsarrhythmia or slow background.
Conclusions:
- EEG is a crucial tool for investigating congenital microcephaly, particularly in ZIKV-affected regions.
- Further research is needed to confirm the association between specific EEG patterns and ZIKV infection.
- Early neuroimaging can aid in the diagnosis and management of microcephaly.
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