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Updated: Feb 12, 2026

Fabrication and Design of Wood-Based High-Performance Composites
Published on: November 9, 2019
Designing phenylalanine-based hybrid biological materials: controlling morphology via molecular composition
Srinivas Mushnoori1, Kassandra Schmidt2, Vikas Nanda3
1Department of Chemical and Biochemical Engineering, Robert Wood Johnson Medical School, Rutgers The State University of New Jersey, Piscataway, New Jersey, USA. meenakshi.dutt@rutgers.edu.
Abstract:
Harnessing the self-assembly of peptide sequences has demonstrated great promise in the domain of creating high precision shape-tunable biomaterials. The unique properties of peptides allow for a building block approach to material design. In this study, self-assembly of mixed systems encompassing two peptide sequences with identical hydrophobic regions and distinct polar segments is investigated. The two peptide sequences are diphenylalanine and phenylalanine-asparagine-phenylalanine. The study examines the impact of molecular composition (namely, the total peptide concentration and the relative tripeptide concentration) on the morphology of the self-assembled hybrid biological material. We report a rich polymorphism in the assemblies of these peptides and explain the relationship between the peptide sequence, concentration and the morphology of the supramolecular assembly.
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