A simulation study comparing nine mathematical models of arterial input function for dynamic contrast enhanced MRI to...

Due to large inter- and intra-patient variabilities of arterial input functions (AIFs), accurately modeling and using patient-specific AIF are very important for quantitative analysis of dynamic contrast enhanced MRI. Computer simulations were performed to evaluate and compare nine population AIF models with the Parker AIF used as 'gold standard'. The Parker AIF was calculated with a temporal resolution of 1.5 s, and then the other nine AIF models were used to fit the Parker AIF. A total of 100 randomly generated volume transfer constants (K^trans) and distribution volumes (v_e) were used to calculate the contrast agent concentration curves based on the Parker AIF and the extended Tofts model with blood plasma volume (v_p) = 0.0, 0.01, 0.05 and 0.10. Subsequently, nine AIF models were used to fit these curves to extract physiological parameters (K^trans, v_e and v_p). The agreements between generated and extracted K^trans and v_e values were evaluated using Bland-Altman analysis. The effects of the second pass of the Parker AIF model with and without adding Rician noise on extracted physiological parameters were evaluated by 1000 simulations using one of the nine mathematical AIF models closest to the Parker model with the smallest number of parameters. The results demonstrated that a six-parameter linear function plus bi-exponential function AIF model was almost equivalent to the Parker AIF and that the corresponding generated and extracted K^trans and v_e were in excellent agreements. The effects of the second pass of contrast agent circulation were small on extracted physiological parameters using the extended Tofts model, unless noise was added with signal to noise ratio less than 10 dB.