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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
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CD137: A checkpoint regulator involved in atherosclerosis.
Leif Å Söderström1, Laura Tarnawski2, Peder S Olofsson3
1Experimental Cardiovascular Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Perioperative Medicine and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden.
Atherosclerosis
|March 24, 2018
Summary
Inflammation drives atherosclerosis. CD137, a costimulatory molecule, promotes vascular inflammation and atherosclerotic plaque development, suggesting it as a therapeutic target for cardiovascular disease.
Area of Science:
- Immunology
- Cardiovascular Science
- Inflammation Research
Background:
- Inflammation is integral to atherosclerotic plaque progression, myocardial infarction, and stroke.
- Costimulatory molecules regulate immune responses and are implicated in atherosclerosis development.
- CD137, a costimulatory molecule, is increasingly recognized for its role in vascular inflammation.
Purpose of the Study:
- To review the immunobiology of CD137.
- To explore the role of CD137 in the development of atherosclerosis and vascular inflammation.
- To assess the potential of CD137-targeted therapies for cardiovascular disease.
Main Methods:
- Literature review of existing studies on CD137.
- Analysis of experimental models investigating CD137 in atherosclerosis.
- Synthesis of data on costimulator function in cardiovascular disease.
Main Results:
- CD137 promotes atherosclerosis and vascular inflammation in experimental models.
- Evidence suggests CD137 is a key regulator in immune responses relevant to cardiovascular disease.
- CD137-targeted therapies are under consideration for clinical application.
Conclusions:
- CD137 plays a significant role in promoting atherosclerosis and vascular inflammation.
- Understanding CD137 immunobiology is crucial for developing targeted cardiovascular therapies.
- CD137 represents a potential therapeutic target for mitigating cardiovascular disease progression.
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