Related Experiment Video
Updated: Feb 12, 2026
09:49
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
10.5K
Pre-operative quantification of pulmonary function using hybrid-SPECT/low-dose-CT: A pilot study.
Philipp Genseke1, Christoph Wetz2, Thekla Wallbaum1
1Department for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
Lung Cancer (Amsterdam, Netherlands)
|March 25, 2018
Summary
Pulmonary perfusion scintigraphy (PS) and SPECT/low-dose-CT (SPECT/ldCT) show significant differences in lobar function estimation. Semi-automatic SPECT/ldCT analysis offers a viable method for assessing lung perfusion in patients with pulmonary malignancies.
Area of Science:
- Pulmonary imaging and functional assessment.
- Radiology and nuclear medicine.
Background:
- Pre-operative lobar function estimation is crucial for patients with pulmonary malignancies and compromised lung function.
- Planar scintigraphy (PS) is commonly used, but its accuracy compared to advanced imaging needs evaluation.
Purpose of the Study:
- To compare lobar perfusion determined by planar scintigraphy (PS) with data from SPECT/low-dose-CT (SPECT/ldCT).
- To evaluate manual and semi-automatic analysis methods for SPECT/ldCT data in assessing lobar perfusion.
Main Methods:
- Retrospective analysis of 39 patients undergoing pulmonary perfusion scintigraphy.
- Imaging acquired using SPECT/low-dose-CT (SPECT/ldCT).
- Lobar perfusion data analyzed manually and via semi-automatic software; reader confidence and interrater agreement assessed.
Main Results:
- Significant differences in lobar perfusion quantification between PS and SPECT/ldCT (manual and semi-automatic).
- High interrater agreement (κ=0.98) for reader confidence in 3D-segmentation.
- Correlation coefficients (rho) ranged from 0.37 to 0.44, indicating moderate agreement.
Conclusions:
- Quantification of lobar perfusion by SPECT/ldCT significantly differs from planar scintigraphy.
- Semi-automatic SPECT/ldCT analysis presents an applicable methodology for lobar perfusion assessment.
- Findings may influence therapeutic decisions in patients with pulmonary malignancies.
Related Concept Videos
01:25Pulmonary Function Tests
859
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
859
01:28Cardiomyopathy VII: Pre and Post Operative Nursing Management
372
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
372
01:14Imaging Studies I: CT and MRI
921
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
921
01:28Imaging Studies for Cardiovascular System V: CT
383
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
383
01:21Pilot and Numeric Relaying
496
Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
496
01:11Bioavailability Study Design: Single Versus Multiple Dose Studies
251
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
251