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Risk factors for multidrug-resistant Gram-negative bacteria infection in intensive care units: A meta-analysis

Hui Ang1, Xuan Sun2

  • 1Medical School, Yangtze University, Jingzhou, Hubei, China.

International Journal of Nursing Practice
|March 26, 2018
PubMed
Abstract

Insights

Male gender, surgery, catheters, ventilation, and prior antibiotics increase the risk of multidrug-resistant Gram-negative bacterial infections in ICUs. These findings aid in developing targeted clinical prevention strategies.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Rising global population and economic development contribute to increased bacterial drug resistance.
  • Drug-resistant bacteria, particularly in intensive care units (ICUs), pose a significant mortality risk.
  • Understanding risk factors is crucial for effective control of multidrug-resistant Gram-negative bacteria.

Purpose of the Study:

  • To systematically identify risk factors for multidrug-resistant Gram-negative bacterial infections in ICUs.
  • To provide an evidence base for clinical measures and antimicrobial stewardship.
  • To inform infection control strategies in critical care settings.

Main Methods:

  • A systematic literature search of case-control and cohort studies published between January 1999 and March 2017.
  • Searches were conducted in major databases: Cochrane Library, PubMed, Web of Science, and Medline.
  • Meta-analysis was performed using StataSE version 12.0.

Main Results:

  • Eighteen studies comprising 235 publications were included in the meta-analysis.
  • Identified risk factors for multidrug-resistant Gram-negative bacterial infections include male gender, operative procedures, central venous catheters, mechanical ventilation, previous antibiotic therapy, and length of ICU stay.
  • Diabetes mellitus was not identified as a risk factor in this analysis.

Conclusions:

  • Six key risk factors are associated with multidrug-resistant Gram-negative bacterial infections in intensive care units.
  • Effective strategies require robust antimicrobial stewardship programs.
  • Enhanced infection control practices and preventative care by medical staff are essential.
Keywords:
intensive care unitsmeta-analysismultidrug-resistant Gram-negative bacteriarisk factors

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