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Updated: Feb 12, 2026

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons
Published on: November 20, 2018
The active role of Ca2+ ions in Aβ-mediated membrane damage
Michele F M Sciacca1, Irene Monaco, Carmelo La Rosa
1Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Sede Secondaria di Catania, Via Paolo Gaifami 18, 95126, Catania, Italy. danilo.milardi@cnr.it.
Abstract:
Calcium dysregulation, membrane leakage and Aβ amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies.
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