Related Experiment Video
Updated: Feb 12, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
Published on: June 28, 2021
Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro
I A Lyakhova1, I S Bryukhovetsky2,3, I V Kudryavtsev2
1Biomedicine School, Far-Eastern Federal University, Vladivostok, Russia. liakhova.ia@dvfu.ru.
Abstract:
Antitumor efficiency of fascaplysin synthetic derivatives (7-phenylfascaplysin, 3-chlorofascaplysin, 3-bromofascaplysin, and 10-bromofascaplysin) was compared out in vitro on C6 glioma cells. The cytotoxic efficiency of all tested compounds was higher than that of unsubstituted fascaplysin; 3-bromofascaplysin and 7-phenylfascaplysin exhibited the best capacity to kill glioma C6 cells. Apoptosis was the main mechanism of glioma cell death. The cytotoxic activity of these compounds increased with prolongation of exposure to the substance and increase of its concentration. Fascaplysin derivatives modified all phases of glioma cell vital cycle. The count of viable tumor cell in G0 phase remained minimum by the end of experiment under the effects of 3-bromofascaplysin and 7-phenylfascaplysin.
Related Concept Videos
Measurement: Derived Units
In Vitro Drug Dissolution: Compendial Testing Models I
In Vitro Drug Dissolution: Compendial Testing Models II
Primary Active Transport
Higher Derivatives
Derivatives

