Related Experiment Video
Updated: Feb 12, 2026

07:45
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
54.7K
Failure-to-Rescue After Acute Myocardial Infarction
Jeffrey H Silber1,2,3,4,5, Alexander F Arriaga3,6, Bijan A Niknam1
1Center for Outcomes Research, Children's Hospital of Philadelphia.
Medical Care
|March 27, 2018
Summary
A new Failure-to-Rescue (FTR) metric adapted for acute myocardial infarction (AMI) effectively measures hospital quality. This tool helps assess care quality for AMI patients by tracking mortality and complications.
Area of Science:
- Cardiology
- Health Services Research
- Quality Improvement
Background:
- Failure-to-Rescue (FTR) is a metric assessing an institution's ability to prevent death in complicated surgical cases.
- Its utility in evaluating care quality for medical conditions like acute myocardial infarction (AMI) is unexplored.
Purpose of the Study:
- To develop and validate a modified Failure-to-Rescue (FTR) metric for analyzing outcomes in acute myocardial infarction (AMI) admissions.
- To assess the metric's ability to reflect hospital quality of care for AMI patients.
Main Methods:
- A split-sample design was used, with 20% of hospitals for definition development, 20% for test characteristic validation, and 60% for out-of-sample validation.
- The study analyzed data from Medicare beneficiaries admitted for AMI between 2009-2011, focusing on 30-day mortality, FTR rates, and in-hospital complications.
Main Results:
- In a 60% out-of-sample validation (234,277 patients, 1142 hospitals), a strong correlation was found between hospital risk-adjusted 30-day mortality and the modified FTR metric (Spearman r=0.89, P<0.0001).
- Hospitals with characteristics like teaching status and advanced cardiac technology showed significantly lower odds of FTR (odds ratio=0.67, P<0.0001).
Conclusions:
- A modified Failure-to-Rescue (FTR) metric can be effectively developed to study the quality of care for acute myocardial infarction (AMI) admissions.
- This metric offers a valuable tool for assessing and improving care quality in cardiovascular medicine.
Related Concept Videos
Acute Respiratory Failure-I
1.1K
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
1.1K
Acute Respiratory Failure-II
1.2K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.2K
Acute Respiratory Failure-V
515
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
515
Acute Respiratory Failure-III
943
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
943
Acute Respiratory Failure-IV
578
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
578
Pathophysiology of Heart Failure
4.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.0K

