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Prognostic Value of Blood Panel Parameters in Patients With Dilated Cardiomyopathy and Advanced Heart Failure

J M Sobrino-Márquez1, A Grande-Trillo1, E M Cantero-Pérez1

  • 1Heart Failure and Heart Transplant Unit, Department of Cardiology, Hospital Universitario Virgen del Rocío, Seville, Spain.

Transplantation Proceedings
|March 28, 2018
PubMed

Insights

Basic blood tests can predict outcomes in patients with dilated cardiomyopathy (DCM) and heart failure. A higher red cell distribution width (RDW) indicates increased risk of mortality or heart transplant, aiding in patient stratification.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Dilated cardiomyopathy (DCM) and left ventricular dysfunction present varied clinical courses.
  • Prognostic markers are crucial for stratifying patients with heart failure.
  • Left ventricular ejection fraction (LVEF) and symptoms alone do not fully predict outcomes.

Purpose of the Study:

  • To determine the prognostic value of basic blood panel parameters in patients with DCM and severe left ventricular dysfunction.
  • To identify simple blood markers for risk stratification in heart failure patients.

Main Methods:

  • Analysis of 87 patients with idiopathic or familial DCM and LVEF <30% from 2009-2011.
  • 5-year follow-up data to assess mortality and heart transplant events.
  • Evaluation of red cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR).

Main Results:

  • Patients with better outcomes had lower RDW, higher lymphocyte counts, and lower NLR.
  • An RDW ≥15% was significantly associated with increased long-term mortality or need for heart transplant.
  • No significant differences in age or sex between survival and non-survival groups.

Conclusions:

  • Basic blood panel parameters, particularly RDW, can serve as useful prognostic tools for heart failure patients.
  • A multimarker strategy may enhance patient stratification in advanced heart failure.
  • Larger studies are needed to validate these findings.
Abstract

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