Related Experiment Video
Updated: Feb 12, 2026

Establishing a Mouse Model of Thin Endometrium
Published on: November 1, 2024
Progesterone, progestins and the endometrium in perimenopause and in menopausal hormone therapy
1a Unité de Gynécologie Endocrinienne , Université Paris Descartes, Hôpitaux Universitaires Port Royal-Cochin , Paris , France.
Abstract:
It is well established that unopposed estrogen for hormone therapy in postmenopausal women (MHT) induces a dose-related stimulation of the endometrium associated with an increased risk of hyperplasia and endometrial cancer. Progesterone acts physiologically to counteract the proliferative effects of estradiol during the menstrual cycle. In MHT, progestogens protect the endometrium against the proliferative effects of estrogens in women with a uterus. Recent data suggest that, whereas micronized progesterone is apparently safer for the breast, it could be less efficient than synthetic progestin on the endometrium. An update on progestogen and endometrial safety in MHT is the subject of this review.
Related Concept Videos
Menopause
Types of Hormones
Types of Hormones
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
Hormonal Regulation
Hormonal Regulation
Plant Hormones

