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Updated: Aug 4, 2025
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
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Menopause hormone treatment after cancer
1Université Paris Cité, Paris, France.
Summary
Menopause hormone therapy (MHT) can alleviate cancer treatment symptoms but has contraindications. MHT may be suitable for ovarian and cervical cancers, but requires caution in breast and endometrial cancer survivors.
Area of Science:
- Oncology
- Gynecology
- Endocrinology
Background:
- Cancer survivors often experience severe menopausal symptoms impacting quality of life.
- Menopause hormone therapy (MHT) is effective for symptom relief but its use in cancer patients is complex.
- Estrogen deficiency long-term effects can be mitigated by MHT, but oncologic contraindications exist.
Purpose of the Study:
- To review the safety and efficacy of MHT in cancer survivors.
- To analyze MHT use in patients with breast, ovarian, endometrial, and cervical cancers.
- To provide guidance on MHT application in various gynecologic cancer contexts.
Main Methods:
- Review of randomized trials and clinical guidelines.
- Analysis of MHT effects based on cancer type and hormone-dependency.
- Evaluation of survival data and symptom management outcomes.
Main Results:
- MHT is generally not recommended for breast cancer survivors.
- Evidence suggests MHT may improve survival in serous high-grade ovarian carcinoma.
- MHT use in endometrial cancer requires further data; progestogen is a safer alternative.
- MHT is permissible for squamous cell cervical carcinoma but restricted for adenocarcinoma.
- Genomic profiling may personalize future MHT decisions.
Conclusions:
- MHT application in cancer survivors is cancer-type specific and requires careful consideration.
- Further research, particularly on molecular profiles, is needed to optimize MHT use.
- Progestogen therapy offers a viable option for symptom management when MHT is contraindicated.
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