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Updated: Feb 12, 2026
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A Modified Method for Heterotopic Mouse Heart Transplantion
Published on: June 23, 2014
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[Heart transplantation in AL amyloidosis]
Pia Dahlberg1, Sven-Erik Bartfay2, Kristjan Karason3
1Sahlgrenska universitetssjukhuset - Kardiologen Göteborg, Sweden Sahlgrenska universitetssjukhuset - Goteborg, Sweden.
Lakartidningen
|March 28, 2018
Summary
Amyloid light chain (AL) amyloidosis can affect the heart. Combining heart transplant with autologous stem cell transplant offers a favorable outcome for AL amyloidosis patients.
Area of Science:
- Cardiology
- Hematology
- Transplantation Medicine
Background:
- Amyloidosis involves protein fibril deposition, causing organ damage.
- Cardiac involvement is common in amyloid light chain (AL) amyloidosis, impacting prognosis and treatment.
- Heart transplantation is typically contraindicated in AL amyloidosis due to recurrence risk.
Observation:
- This study reports on the first two patients with AL amyloidosis treated with heart transplantation followed by autologous stem cell transplantation (ASCT).
- The treatment was administered at Sahlgrenska University Hospital.
Findings:
- Heart transplantation followed by ASCT can lead to a favorable outcome in AL amyloidosis.
- This combined approach addresses the high recurrence risk associated with heart transplantation alone.
Implications:
- This strategy may offer a viable therapeutic option for select AL amyloidosis patients with cardiac involvement.
- Further research is warranted to validate the long-term efficacy and safety of this combined treatment approach.
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