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[The blood-brain barrier in ageing persons]
Nina Haaning1, Else Marie Damsgaard, Torben Moos
1tmoos@hst.aau.dk.
Ugeskrift for Laeger
|March 29, 2018
Summary
Aging and neurodegenerative diseases increase blood-brain barrier (BBB) permeability. Protein buildup in the brain damages BBB cells, reducing barrier proteins. Non-invasive detection of BBB defects is crucial for clinical use.
Area of Science:
- Neuroscience
- Cell Biology
- Vascular Biology
Background:
- Brain capillary endothelial cells (BECs) form the ultra-tight blood-brain barrier (BBB).
- BBB permeability increases with age and in neurovascular and neurodegenerative diseases.
- Defects can be initiated by plasma protein leakage into the brain.
Purpose of the Study:
- To investigate the impact of protein deposition on BECs and BBB integrity.
- To highlight the clinical relevance of detecting BBB defects in aging and neurological disorders.
Main Methods:
- Analysis of protein deposition in perivascular spaces.
- Assessment of the effect of deposited proteins on BECs.
- Evaluation of barrier protein expression in BECs.
Main Results:
- Deposited proteins negatively influence BECs.
- Decreased expression of essential barrier proteins was observed.
- Protein accumulation contributes to BBB dysfunction.
Conclusions:
- Protein deposition in the brain extracellular space impairs BBB function.
- Non-invasive detection methods for BBB defects are clinically relevant for aging populations and patients with severe brain disorders.
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