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Insulin Resistance and β-Cell Dysfunction in Relation to Cardiometabolic Risk Patterns
Tiange Wang1, Zhiyun Zhao1, Yu Xu1
1State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
The Journal of Clinical Endocrinology and Metabolism
|March 29, 2018
Summary
Insulin resistance (IR) and beta-cell dysfunction are key to cardiometabolic disorders. High IR impacts all disorders, while beta-cell dysfunction affects diabetes, dyslipidemia, and hypertension, with combined effects showing distinct risk patterns in Chinese adults.
Area of Science:
- Endocrinology and Metabolism
- Cardiovascular Health
- Public Health
Background:
- Insulin resistance (IR) and beta-cell dysfunction are critical defects in developing diabetes and cardiometabolic disorders.
- Understanding their independent and combined effects is crucial for public health strategies.
Purpose of the Study:
- To investigate the independent and joint associations of IR and beta-cell dysfunction with cardiometabolic disorders.
- To analyze prevalence of obesity, central obesity, diabetes, dyslipidemia, and hypertension in relation to these defects.
Main Methods:
- Utilized data from a nationally representative sample of 93,690 Chinese adults.
- Assessed IR and beta-cell function using the homeostasis model assessment (HOMA-IR and HOMA-B).
Main Results:
- High HOMA-IR independently correlated with all studied cardiometabolic disorders.
- Low HOMA-B independently linked to diabetes, dyslipidemia, and hypertension, but inversely to obesity.
- Joint analysis revealed distinct patterns: diabetes showed strong association with low HOMA-B irrespective of HOMA-IR; dyslipidemia and hypertension had additive associations; obesity was linked only when both IR and beta-cell dysfunction were impaired.
Conclusions:
- IR demonstrated broader associations with cardiometabolic disorders than beta-cell dysfunction.
- Combinations of IR and beta-cell dysfunction exhibit unique relationships with cardiometabolic risk profiles in the Chinese adult population.
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