Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K
Levels of Organization01:09

Levels of Organization

141.7K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
141.7K
Accessory Organs01:31

Accessory Organs

74.5K
Accessory organs are those that participate in the digestion of food but do not come into direct contact with it like the mouth, stomach, or intestine do. Accessory organs secrete enzymes into the digestive tract to facilitate the breakdown of food.
74.5K
Organic Compounds03:02

Organic Compounds

57.6K
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
57.6K
Transgenic Organisms00:53

Transgenic Organisms

33.6K
Overview
33.6K
Organization of Genes02:07

Organization of Genes

73.7K
Overview
73.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cancer detection in the European Randomised Study of Screening for Prostate Cancer (ERSPC).

BJU international·2026
Same author

Diagnosis and Staging of Patients with Prostate Cancer: Report from the 2025 Advanced Prostate Cancer Consensus Conference (APCCC) Diagnostics.

European urology·2026
Same author

Improved prostate cancer grading by incorporating Gleason pattern quantification, invasive cribriform and intraductal carcinoma in the new QUICC-score.

Annals of diagnostic pathology·2026
Same author

[Screening for prostate cancer; a screening program is favored over current opportunistic testing].

Nederlands tijdschrift voor geneeskunde·2026
Same author

From Evidence to Implementation: How Should We Screen for Prostate Cancer in the Modern Era?: Editorial to: Nguyen DD, Tadayon B, Lin L, et al. Effect of Prostate Cancer Screening with Prostate-specific Antigen Testing on Long-term Prostate Cancer-specific Mortality: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Eur Urol. 2026. In press. https://doi.org/10.1016/j.eururo.2026.04.005.

European urology·2026
Same author

Use of Artificial Intelligence in prostate MRI: A rapid scoping review highlighting limited evidence in screening context.

European journal of radiology·2026

Related Experiment Video

Updated: Feb 12, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.7K

Screening for prostate cancer: are organized screening programs necessary?

Monique J Roobol1

  • 1Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Translational Andrology and Urology
|March 30, 2018
PubMed
Summary

Prostate cancer (PCa) screening using prostate-specific antigen (PSA) tests shows reduced mortality but increases overdiagnosis. Guidelines now emphasize shared decision-making and selective screening for high-risk men.

Keywords:
Prostate cancer (PCa)harm and benefitmortalityopportunistic testingover diagnosisprostate-specific antigen (PSA)screening

More Related Videos

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.9K
Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
06:19

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

3.9K

Related Experiment Videos

Last Updated: Feb 12, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.7K
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.9K
Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
06:19

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

3.9K

Area of Science:

  • Urology
  • Oncology
  • Public Health

Background:

  • Prostate-specific antigen (PSA) testing for prostate cancer (PCa) has been controversial since 1991 due to overdiagnosis risks.
  • Randomized controlled trials (RCTs) investigated PSA screening's impact on PCa mortality, confirming both benefits and harms.

Purpose of the Study:

  • To evaluate the effectiveness and challenges of PSA-based prostate cancer screening.
  • To discuss the implications of current screening practices and the need for organized programs.

Main Methods:

  • Review of randomized controlled trials assessing PSA screening for prostate cancer.
  • Analysis of guideline changes and clinical practice implementation regarding PSA testing.
  • Consideration of emerging biomarkers and imaging for selective screening.

Main Results:

  • PSA screening reduces prostate cancer-specific mortality but leads to overdiagnosis and unnecessary procedures.
  • Current guideline implementation is challenging, resulting in inappropriate testing for many men.
  • Emerging diagnostic tools are being explored for organized, selective screening programs.

Conclusions:

  • Organized, selective screening programs are needed to optimize prostate cancer early detection.
  • Shared decision-making and risk stratification are crucial for appropriate PSA testing.
  • Future strategies may involve integrating novel biomarkers and imaging with PSA testing.