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Related Experiment Videos

What Can 'Brown-ing' Do For You?

Amar M Singh1, Stephen Dalton1

  • 1Center for Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA.

Trends in Endocrinology and Metabolism: TEM
|April 3, 2018
PubMed
Summary
This summary is machine-generated.

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Human stem cell models of thermogenic adipocytes offer new therapeutic avenues for metabolic diseases like obesity and type 2 diabetes. These models advance drug screening and understanding of disease development.

Area of Science:

  • Biomedical Science
  • Stem Cell Biology
  • Metabolic Disease Research

Background:

  • Human stem cell-derived thermogenic adipocytes are crucial for metabolic disease research.
  • Existing cell-based platforms utilize pluripotent stem cells, adipose-derived stem cells, and reprogramming techniques.
  • These platforms are vital for drug screening and developing transplantable therapeutics.

Purpose of the Study:

  • To provide a comprehensive overview of stem cell-based approaches for thermogenic adipocyte modeling.
  • To detail the latest advancements, opportunities, and limitations in this field.
  • To discuss the future utility of stem cell platforms in treating metabolic diseases.

Main Methods:

  • Utilizing pluripotent stem cells for adipocyte differentiation.
Keywords:
adipose-derived stem cellsbeige fatbrown fatmesenchymal stem cellsmetabolic diseasepluripotent stem cells

Related Experiment Videos

  • Employing adipose-derived stem cells and preadipocytes.
  • Applying programming-reprogramming strategies for cell development.

    • Main Results:

    • Stem cell-based models enable effective drug screening for metabolic conditions.
    • These models facilitate the study of disease mechanisms and developmental processes.
    • Advancements offer potential for transplantable therapeutics in metabolic disease treatment.

    Conclusions:

    • Stem cell-derived thermogenic adipocytes represent a promising tool for metabolic disease research and therapy.
    • Further development of these platforms can significantly impact type 2 diabetes and obesity treatment.
    • Optimized utilization of stem cell platforms is key to future therapeutic strategies.