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Published on: October 19, 2017
Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives
Michał Prejs1, Grzegorz Cholewiński1, Piotr Trzonkowski2
1a Department of Organic Chemistry , Gdansk University of Technology , Gdansk PL 80-233 , Poland.
Abstract:
New conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2',3'-O-isopropylidene protected and free hydroxyl groups possessing forms. The obtained results were also discussed in terms of selectivity index, defined as SI = IC50/EC50.
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