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Updated: Feb 12, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 27, 2010
Advances in HIV-1 Vaccine Development
Yong Gao1, Paul F McKay2, Jamie F S Mann3
1Department of Microbiology and Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada. ygao387@uwo.ca.
Abstract:
An efficacious HIV-1 vaccine is regarded as the best way to halt the ongoing HIV-1 epidemic. However, despite significant efforts to develop a safe and effective vaccine, the modestly protective RV144 trial remains the only efficacy trial to provide some level of protection against HIV-1 acquisition. This review will outline the history of HIV vaccine development, novel technologies being applied to HIV vaccinology and immunogen design, as well as the studies that are ongoing to advance our understanding of vaccine-induced immune correlates of protection.
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