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Risk factors for long-term mortality in patients admitted with severe infection
J Francisco1, I Aragão2, T Cardoso2
1Serviço de Medicina, Hospital de Santo António, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal. joaop.dinis@gmail.com.
BMC Infectious Diseases
|April 7, 2018
Summary
Long-term mortality after severe infection is linked to patient age, cancer, functional status, and specific pathogens. Understanding these risk factors aids in prognosis and clinical decisions for severe infections.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Epidemiology
Background:
- Severe infections are a significant cause of mortality.
- Identifying long-term mortality risk factors in hospitalized patients is crucial.
Purpose of the Study:
- To describe risk factors for long-term mortality among inpatients with severe infection.
- To inform prognosis and clinical decision-making.
Main Methods:
- Prospective cohort study of 1013 patients admitted with severe infection over one year.
- Analysis of patient background and infectious episode variables using multiple logistic regression.
- Development of two models to predict 5-year mortality, with and without acute-illness severity scores.
Main Results:
- Key predictors of 5-year mortality included age, cancer, Karnofsky Index, positive blood cultures, and ESKAPE pathogen infections.
- Absence of comorbidities was associated with lower mortality.
- Models showed good discrimination power (AU-ROC 0.80-0.81).
Conclusions:
- Age, prior comorbidities, functional status, and ESKAPE pathogen infections consistently predict long-term outcomes.
- Findings support individualized prognosis discussions and clinical management strategies.
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