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Targeted Therapy and Immunotherapy in the Treatment of Non-Small Cell Lung Cancer

Girish S Shroff1, Patricia M de Groot1, Vassiliki A Papadimitrakopoulou2

  • 1Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Radiologic Clinics of North America
|April 7, 2018
PubMed

Insights

Advanced non-small cell lung cancer (NSCLC) treatment now uses targeted therapy and immunotherapy. These approaches personalize care by targeting mutations and stimulating the immune system to fight cancer effectively.

Area of Science:

  • Oncology
  • Immunology
  • Radiology

Background:

  • Treatment for advanced non-small cell lung cancer (NSCLC) has shifted from chemotherapy to personalized medicine.
  • This personalized approach utilizes histology and molecular markers from primary tumors.
  • Key advancements include targeted therapies and immunotherapies.

Purpose of the Study:

  • To review the roles of targeted therapy and immunotherapy in treating NSCLC.
  • To describe imaging patterns associated with these advanced treatments.
  • To outline immune-related adverse events linked to immunotherapy.

Main Methods:

  • Literature review and synthesis of current research on NSCLC treatments.
  • Analysis of imaging findings related to targeted therapy and immunotherapy efficacy.
  • Compilation of data on immune-related adverse events.

Main Results:

  • Targeted therapies focus on oncogenic driver mutations.
  • Immunotherapy enhances the host immune system's ability to recognize and attack cancer cells.
  • Imaging plays a crucial role in monitoring treatment response and disease patterns.

Conclusions:

  • Personalized medicine, including targeted therapy and immunotherapy, represents a significant evolution in NSCLC management.
  • Understanding imaging patterns and potential immune-related adverse events is essential for optimal patient care.
Keywords:
ImmunotherapyLung cancerTargeted therapy

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