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Related Experiment Video

Updated: Feb 12, 2026

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
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NKT cells in liver diseases.

Shasha Zhu1,2, Huimin Zhang1,2, Li Bai3,4

  • 1CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, 230027, China.

Frontiers of Medicine
|April 7, 2018
PubMed
Summary

Natural killer T cells (NKTs) are crucial immune cells in the liver. This review explores their complex roles in various liver diseases, highlighting dynamic changes during disease progression.

Keywords:
alcoholic liver diseaseautoimmune liver diseaseshepatitis B virus and hepatitis C virus infectionhepatocellular carcinomanatural killer T cellsnonalcoholic fatty liver disease

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Area of Science:

  • Immunology
  • Hepatology
  • Cell Biology

Background:

  • Natural killer T cells (NKTs) are innate-like, tissue-resident lymphocytes recognizing lipid antigens.
  • NKTs are abundant in the liver and implicated in immunity, autoimmunity, and metabolic diseases.

Purpose of the Study:

  • To review current knowledge on NKT cell biology.
  • To elucidate the multifaceted roles of NKTs in liver diseases, including viral hepatitis, autoimmune liver conditions, alcoholic and nonalcoholic fatty liver disease, and hepatocellular carcinoma.

Main Methods:

  • Literature review and synthesis of recent findings.
  • Discussion of controversial results and dynamic alterations in NKT cell function.

Main Results:

  • NKT cells exhibit dynamic alterations in their roles during liver disease progression.
  • Changes in NKT subsets, cytokine profiles, and intercellular crosstalk influence NKT function.

Conclusions:

  • The role of NKT cells in liver diseases is complex and context-dependent.
  • Understanding these dynamics is crucial for therapeutic strategies targeting NKT cells in liver pathology.