Related Experiment Video
Updated: Feb 12, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
[Evaluation of the coagulometer STA R Max® (Stago) for routine coagulation parameters]
Justine Brulé1, Thomas Sinegre1, Bruno Pereira2
1Service d'hématologie biologique, CHU de Clermont-Ferrand, Hôpital Estaing, Clermont-Ferrand, France.
Abstract:
The STA R Max® is a fully automated multiparameter coagulometer using clotting (viscosity-based detection system), chromogenic and immunologic assays. STA R Max® is equipped with an innovative software (STA Coag Expert®) designed to assist laboratory in accreditation. The aim of this study was to evaluate its performances for the certification according to ISO 15189 quality standard in the haemostasis unit of our university hospital. The following tests were evaluated: prothrombin time (PT), activated partial thromboplastin time (aPTT), kaolin cephalin clotting time (KCCT), fibrinogen, anti-Xa assay and D-dimers. In normal and pathological range, the intra-assay coefficients of variation (CV) for PT, aPTT, KCCT and fibrinogen were below 4.0%. Intra-assay CV was of 4.0% for the anti-Xa assay and intra-assay CV was of 7.9% for D-dimers. Inter-assay CV were below 5.0% for PT, aPPT, KCCT and fibrinogen, 14.9% for anti-Xa assay and 8.6% for D-dimers. The interlaboratory comparisons were below 8.7% for PT, aPPT and KCCT, 5.0% for fibrinogen and 15.5% for anti-Xa assay. All results were acceptable according to suitable CV established by GFHT and the provider. The concordance between all coagulometers was excellent, with correlation coefficient close to 1 (0.99 for all parameters except for aPPT which was 0.98) calculated thanks to an intra-class correlation study. In conclusion, the STA R Max® analyser is suitable for haemostasis laboratories and facilitates certification of a laboratory.
Related Concept Videos
Coagulation
Coagulation
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Wave Parameters
Self-Evaluation: Self-Enhancement and Self-Verification
Distributions to Estimate Population Parameter
Dosage Regimens: Partial Pharmacokinetic Parameters

