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Updated: Feb 12, 2026

Perspectives on Neuroscience
Published on: July 31, 2007
Cancer dormancy and criticality from a game theory perspective
Amy Wu1, David Liao2, Vlamimir Kirilin3
1Banter AI, 408 Florence St., Palo Alto CA, 94301 USA.
Background:
The physics of cancer dormancy, the time between initial cancer treatment and re-emergence after a protracted period, is a puzzle. Cancer cells interact with host cells via complex, non-linear population dynamics, which can lead to very non-intuitive but perhaps deterministic and understandable progression dynamics of cancer and dormancy.
Results:
We explore here the dynamics of host-cancer cell populations in the presence of (1) payoffs gradients and (2) perturbations due to cell migration.
Conclusions:
We determine to what extent the time-dependence of the populations can be quantitively understood in spite of the underlying complexity of the individual agents and model the phenomena of dormancy.
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