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Updated: Feb 12, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Pd-Catalyzed Decarboxylative Sonogashira Reaction via Decarboxylative Bromination
Quandi Jiang1,2, Hongyi Li1,2, Xiaofeng Zhang1
1State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis , Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Fuzhou 350002 , People's Republic of China.
Abstract:
The decarboxylative alkynylation of (hetero)aryl carboxylic acids with terminal alkynes has been achieved by using a Pd(PPh3)4/PCy3 catalyst. This Pd-catalyzed method exhibits good functional group tolerance for both coupling partners and enables chemical modification of complex molecules. The establishment of this decarboxylative alkynylation reaction is attributed to the discovery of a highly selective decarboxylative bromination of (hetero)aryl carboxylic acids with NBS ( N-bromosuccinimide).
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