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Updated: Feb 12, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Imaging Macrophage-associated Inflammation

Catherine A Foss1, Julian Sanchez-Bautista2, Sanjay K Jain2

  • 1Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD.

Seminars in Nuclear Medicine
|April 9, 2018
PubMed

Insights

Activated macrophages play a key role in inflammatory diseases like tuberculosis and atherosclerosis. Developing noninvasive imaging for these cells could aid disease diagnosis and treatment monitoring.

Area of Science:

  • Immunology
  • Cell Biology
  • Medical Imaging

Background:

  • Macrophages are crucial immune cells originating from bone marrow monocytes.
  • Activated macrophages are implicated in the pathogenesis of various inflammatory and infectious diseases, including tuberculosis, sarcoidosis, Crohn's disease, and atherosclerosis.

Purpose of the Study:

  • To highlight the significance of activated macrophages in disease.
  • To emphasize the need for noninvasive imaging techniques targeting activated macrophages.

Main Methods:

  • Review of current understanding of macrophage biology and their role in disease.
  • Discussion of the potential of advanced imaging modalities.

Main Results:

  • Activated macrophages are central to the pathology of several significant human diseases.
  • Current imaging techniques lack specificity for activated macrophages.

Conclusions:

  • Noninvasive imaging of activated macrophages holds promise for improved disease differentiation.
  • Targeted imaging could facilitate monitoring of therapeutic interventions in inflammatory conditions.

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