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Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
Innovative Nanoparticle-based Therapeutic Strategies: Overcoming Biological Barriers for Enhanced Efficacy.
Sunny Rathee1,2, Sakshi Soni1, Debasis Sen1
1Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University), Sagar, M.P., 470003, India.
Current Drug Targets
|May 15, 2026
Summary
Overcoming the Blood-Brain Barrier (BBB) is crucial for Central Nervous System (CNS) drug delivery. This review explores innovative nanoparticle strategies to enhance drug transport across the BBB for neurological disorder treatments.
Area of Science:
- Neuroscience
- Pharmacology
- Biotechnology
Background:
- The Blood-Brain Barrier (BBB) restricts Central Nervous System (CNS) drug entry.
- Its structure involves endothelial cells, pericytes, astrocytic end-feet, and tight junctions.
- Selective transport mechanisms regulate molecule passage, maintaining CNS homeostasis.
Purpose of the Study:
- To comprehensively review the BBB's structure, physiology, and challenges.
- To examine innovative strategies for enhancing CNS drug delivery.
- To synthesize recent advancements in BBB permeation for neurological therapies.
Main Methods:
- Review of anatomical and physiological aspects of the BBB.
- Analysis of various endogenous transport mechanisms (carrier-mediated, receptor-mediated, absorptive-mediated, efflux).
- Exploration of nanotechnology-based approaches using engineered nanoparticles (liposomes, SLNs, polymeric, inorganic).
Main Results:
- Nanoparticles (liposomes, SLNs, polymeric, inorganic) engineered for size, shape, and charge can traverse the BBB.
- Drug loading strategies (covalent, non-covalent) and ligand incorporation improve nanoparticle efficacy.
- Surface modifications enhance BBB penetration and targeting for therapeutic delivery.
Conclusions:
- Effective CNS drug delivery requires overcoming BBB challenges.
- Nanotechnology offers promising solutions for targeted drug transport across the BBB.
- Advancements in BBB permeation strategies are vital for developing novel neurological disorder treatments.
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