Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.7K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.7K
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering the Lymphatic Vasculature: Current Concepts and Challenges from Preclinical Strategies to Clinical Practice.

Seminars in plastic surgery·2026
Same author

Comparative Efficacy of Stromal Vascular Fraction and Adipose-derived Stem Cells in UVB-induced Skin Damage in Nude Mice.

Aesthetic surgery journal·2025
Same author

Transplantation of engineered vascularized lymphatic tissue using LEC and in vivo AV loop model to enhance lymphangiogenesis and restore lymphatic drainage in a lymphadenectomy rat model.

Journal of tissue engineering·2025
Same author

Smartphone-assisted tuberculosis detection by a smart amplification process and lateral flow immunoassay with a 3D-printed device.

Chemical communications (Cambridge, England)·2025
Same author

Microplastic and nanoplastic exposure and risk of diabetes mellitus.

World journal of clinical cases·2025
Same author

Manipulating Mg/Ca ratios in MgO-CaO-SiO<sub>2</sub> bioactive glass for achieving accelerated osteogenic differentiation of human adipose-derived stem cells.

Biomaterials advances·2025
Same journal

Mitochondria produce lactate to vent redox pressure.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Beyond fat storage: neuronal lipid droplets regulate whole-body metabolism.

Trends in endocrinology and metabolism: TEM·2026
Same journal

HDL resuscitates cells from ferroptosis.

Trends in endocrinology and metabolism: TEM·2026
Same journal

2-Methylbutyrylcarnitine (2MBC).

Trends in endocrinology and metabolism: TEM·2026
Same journal

Decoding growth hormone actions on human growth plate stem cells.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Androgen loss backfires: Brain gate for tumor immunity.

Trends in endocrinology and metabolism: TEM·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.4K

Functional Interaction between Melatonin Signaling and Noncoding RNAs.

Shih-Chi Su1, Russel J Reiter2, Hui-Yi Hsiao3

  • 1Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou and Keelung, Taiwan.

Trends in Endocrinology and Metabolism: TEM
|April 11, 2018
PubMed
Summary
This summary is machine-generated.

Melatonin influences noncoding RNAs (ncRNAs) in various conditions, and ncRNAs also regulate melatonin synthesis. This review explores these interactions for future research into melatonin and the noncoding transcriptome.

Keywords:
lncRNAmelatoninmiRNAnoncoding RNAs

More Related Videos

Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Related Experiment Videos

Last Updated: Feb 12, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.4K
Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Chronobiology

Background:

  • Melatonin, a hormone from the pineal gland, synchronizes circadian rhythms.
  • Melatonin's functions extend beyond protein interactions to influencing noncoding RNAs (ncRNAs).

Purpose of the Study:

  • To review the current understanding of melatonin's modulation of ncRNA pathways.
  • To explore the reciprocal impact of ncRNAs on melatonin synthesis.
  • To provide a foundation for future research on melatonin and the noncoding transcriptome.

Main Methods:

  • Literature review of studies on melatonin and noncoding RNAs.
  • Analysis of physiological and pathological conditions involving melatonin-ncRNA interactions.
  • Examination of ncRNAs that regulate melatonin synthesis.

Main Results:

  • Melatonin modulates diverse ncRNA pathways in various physiological and pathological states.
  • Specific ncRNAs play a role in controlling melatonin production.
  • The interplay between melatonin and ncRNAs is complex and bidirectional.

Conclusions:

  • Understanding melatonin's interaction with ncRNAs is crucial for exploring its broad-spectrum actions.
  • Further research into the noncoding transcriptome's role in melatonin pathways is warranted.
  • This review highlights emerging functions of ncRNAs in endocrinology and chronobiology.