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Maximising platelet availability by delaying cold storage
B Wood1, L Johnson1, R A Hyland1
1Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia.
Vox Sanguinis
|April 11, 2018
Summary
Storing platelets conventionally then switching to cold storage near expiry maintains quality. This delayed-cold storage method offers a viable strategy to extend platelet shelf life and maximize inventory for critical bleeding events.
Area of Science:
- Transfusion Medicine
- Hematology
- Blood Product Storage
Background:
- Conventional room temperature (RT) platelet storage has limitations.
- Cold-stored platelets exhibit rapid clearance, impacting prophylactic transfusion efficacy.
- Platelet wastage is a significant concern in blood banking.
Purpose of the Study:
- To evaluate the feasibility of a delayed-cold storage strategy for platelets.
- To compare the in vitro quality of delayed-cold stored platelets with continuously cold-stored platelets.
- To assess the potential of this method for extending platelet shelf life and optimizing inventory.
Main Methods:
- Matched pairs of buffy-coat-derived platelets were used (n=8).
- One unit underwent continuous cold storage (2-6°C).
- The second unit (delayed-cold) was stored at RT (20-24°C) for 4 days, then transferred to cold storage (2-6°C). In vitro quality was assessed over 21 days.
Main Results:
- Both storage methods maintained similar platelet counts.
- Delayed-cold platelets showed significantly higher pH and HSR but comparable metabolic markers.
- Platelet activation markers (phosphatidylserine, CD62P) and microparticle release were similar between groups.
- Aggregation responses in delayed-cold platelets mirrored those of cold-stored platelets after transfer.
Conclusions:
- Delayed-cold storage results in comparable metabolic and activation profiles to continuous cold storage.
- Transferring platelets to refrigerated storage near expiry is a viable strategy.
- This approach can potentially maximize platelet inventories for transfusion services.
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