FORMULATION AND EVALUATION OF MICROSPHERES CONTAINING LOSARTAN POTASSIUM BY SPRAY-DRYING TECHNIQUE

Area of Science:

• Pharmaceutical Technology
• Drug Delivery Systems
• Materials Science

Background:

• Microspheres offer versatile drug delivery but their application with cardiac medications is underexplored.
• Controlled release formulations aim to improve therapeutic efficacy and patient compliance by reducing dosing frequency.

Purpose of the Study:

• To investigate the preparation of losartan potassium microspheres using Eudragit L30D55.
• To evaluate the controlled release characteristics and effect of excipients on microsphere quality.
• To assess the suitability of spray-drying for producing cardiac medication microspheres.

Main Methods:

• Losartan potassium microspheres were prepared using the spray-drying technique.
• Eudragit L30D55 served as the polymer matrix for encapsulation.
• Microsphere morphology, size, and drug release kinetics were analyzed.

Main Results:

• Spray-drying yielded microspheres with appropriate size and morphology.
• Drug release kinetics followed first- and/or zero-order models.
• The formulation demonstrated sustained release of losartan potassium for up to 12 hours.

Conclusions:

• Spray-drying and Eudragit L30D55 are effective for preparing losartan potassium microspheres.
• The developed microspheres enable controlled drug release, potentially reducing dosing frequency.
• This approach shows promise for improved cardiac medication delivery.