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DEVELOPMENT AND CHARACTERIZATION OF SMART DRUG DELIVERY SYSTEM
Acta Poloniae Pharmaceutica
|April 13, 2018
Summary
Researchers developed a novel pH-sensitive polymer for smart drug delivery. The best formulation, CMA2, showed excellent swelling and drug release for acid-labile medications.
Area of Science:
- Polymer Chemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Highly acid-labile drugs require specialized delivery systems to prevent degradation in the stomach.
- Smart drug delivery systems offer targeted release, improving therapeutic efficacy and reducing side effects.
Purpose of the Study:
- To develop and evaluate a novel pH-sensitive polymer-based drug carrier.
- To create a smart drug delivery system for highly acid-labile drugs using free radical polymerization.
- To optimize the formulation for enhanced drug release at specific pH levels.
Main Methods:
- Free radical polymerization using carboxymethyl cellulose, methacrylic acid, potassium persulfate, and N,N methylene bisacrylamide.
- Characterization via swelling analysis at acidic and basic pH, SEM, FTIR, and thermal analysis.
- Evaluation of pH-responsive release of rabeprazole sodium as a model drug.
Main Results:
- pH-responsive swelling and drug release were directly correlated with methacrylic acid concentration.
- Increased methacrylic acid enhanced swelling at basic pH, while higher crosslinker content reduced swelling.
- Formulation CMA2 demonstrated superior pH-sensitive swelling and cumulative drug release at alkaline pH.
Conclusions:
- The developed crosslinked polymer exhibits significant pH-responsive properties suitable for drug delivery.
- Methacrylic acid concentration is a key factor in tuning the swelling and release characteristics.
- CMA2 is identified as a promising candidate for a smart drug carrier for acid-labile drugs.
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