Lambert-Eaton Myasthenic Syndrome
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Updated: Feb 11, 2026

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Vita G Kesner1, Shin J Oh2, Mazen M Dimachkie3
1Neurology Department, 12 Executive Park Drive NE, Atlanta, GA 30329, USA.
Abstract:
Lambert-Eaton myasthenic syndrome is a paraneoplastic or primary autoimmune neuromuscular junction disorder characterized by proximal weakness, autonomic dysfunction and ariflexia. The characteristic symptoms are thought to be caused by antibodies generated against the P/Q-type voltage-gated calcium channels present on presynaptic nerve terminals and by diminished release of acetylcholine. More than half of Lambert-Eaton myasthenic syndrome cases are associated with small cell lung carcinoma. Diagnosis is confirmed by serologic testing and electrophysiologic studies. 3,4-diaminopyridine is effective symptomatic treatment of LEMS.
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