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Obstructive Sleep Apnea as a Risk Factor for Atrial Fibrillation: A Meta-Analysis
Irini Youssef1, Haroon Kamran1, Mena Yacoub2
1Department of Medicine, Divisions of Endocrinology, Cardiology and Renal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Journal of Sleep Disorders & Therapy
|April 17, 2018
Summary
Obstructive Sleep Apnea (OSA) significantly increases the risk of developing Atrial Fibrillation (AF). This meta-analysis confirms a strong association, highlighting OSA/SDB patients as high-risk for AF development.
Area of Science:
- Cardiology
- Sleep Medicine
- Public Health
Background:
- Atrial Fibrillation (AF) is a growing health concern with serious consequences.
- Obstructive Sleep Apnea (OSA), also known as sleep disordered breathing (SDB), is a prevalent condition.
- Understanding the link between OSA/SDB and AF is crucial for risk stratification and management.
Purpose of the Study:
- To conduct a meta-analysis assessing the relationship between Obstructive Sleep Apnea (OSA) and the risk of Atrial Fibrillation (AF).
- To quantify the risk of AF in individuals diagnosed with OSA/SDB compared to controls.
Main Methods:
- Systematic literature search of PUBMED, Medline, and Cochrane Library using keywords: "atrial fibrillation", "obstructive sleep apnea", and "sleep disordered breathing (SDB)".
- Inclusion of studies with confirmed OSA/SDB diagnosis and comparison of AF occurrence.
- Meta-analysis performed using Comprehensive Meta-Analysis package V3.
Main Results:
- Nine studies involving 19,837 participants were included after rigorous screening.
- The risk of AF was significantly higher in patients with OSA/SDB compared to the control group (OR: 2.120, CI: 1.845-2.436, p < 0.001).
- Moderate heterogeneity was observed across the pooled analysis (I-squared: 64.424).
Conclusions:
- Obstructive Sleep Apnea/Sleep Disordered Breathing is strongly associated with Atrial Fibrillation.
- Individuals with OSA/SDB represent a high-risk population for AF development.
- Further prospective research is warranted to evaluate the impact of OSA/SDB treatment on AF prevention.
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