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Bach2: An Instrument of Heterogeneity for Long-Term Protection
Qiutong Huang1, Gabrielle T Belz1
1Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria, 3052, Australia; Department of Molecular Biology, University of Melbourne, Parkville, Melbourne, Victoria, 3010.
Abstract:
Generation of functionally diverse effector and memory killer T cells is essential for immediate and long-term protective immunity. Herndler-Brandstetter et al. (2018) report that Bach2 promotes functional plasticity of effector T cells and the transition into the long-term memory compartment by regulating the expression of the inhibitory receptor KLRG1.
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