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Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
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Dendrimers for Drug Delivery.
1School of Pharmacy, Medical College of Wisconsin, 8701 W Watertown Plank Road, Milwaukee, WI 53226, USA. achauhan@mcw.edu.
Molecules (Basel, Switzerland)
|April 20, 2018
Summary
Poly(amidoamine) (PAMAM) dendrimers enhance drug delivery by improving solubility, stability, and bioavailability. These versatile nanostructures offer controlled release and targeted delivery for next-generation nanodevices.
Area of Science:
- Polymer Chemistry
- Nanotechnology
- Materials Science
Background:
- Dendrimers, a unique class of polymers, were first described in 1985.
- Their application in drug delivery systems emerged in the late 1990s.
- Poly(amidoamine) (PAMAM) dendrimers are a prominent example.
Purpose of the Study:
- To demonstrate the utility of PAMAM dendrimers in drug delivery.
- To explore methods for controlling drug entrapment and release.
- To highlight the potential of dendrimer nanotechnology for advanced nanodevices.
Main Methods:
- Utilizing two primary approaches: formulation (physical entrapment) and nanoconstruct (covalent coupling).
- Modifying dendrimer surfaces and generations to control drug interactions.
- Engineering dendrimer platforms with targeting ligands and imaging molecules.
Main Results:
- PAMAM dendrimers significantly enhance drug solubility, stability, and oral bioavailability.
- Controlled drug release and entrapment achieved through surface and generation modification.
- Demonstrated increased transdermal permeation and specific drug targeting capabilities.
Conclusions:
- PAMAM dendrimers offer a versatile platform for advanced drug delivery systems.
- Dendrimer nanotechnology enables the creation of multifunctional nanodevices for targeted therapies.
- Further development holds potential for next-generation nanomedical applications.
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