[MECHANISMS OF NEURONAL LOSS IN ALZHEIMER''S DISEASE]

One of the main elements of the pathogenesis of Alzheimer's disease is neuronal loss in different areas of the brain, which is more intensive than in normal aging. Necessity of studying the pathogenesis of this process is determined by the fact that the loss of neurons begins at the preclinical stage of Alzheimer's disease when the amyloid plaques and neurofibrillary tangles (main morphological manifestations of the disease) is not yet formed and that the loss of neurons correlates with the severity of clinical symptoms. To date, there is evidence that allows delineating probable pathogenetic mechanisms of neuronal loss. This is the purpose of this review of the literature.