Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

56.1K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.1K
The Nucleosome Core Particle02:10

The Nucleosome Core Particle

14.6K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
14.6K
Measurement: Derived Units03:02

Measurement: Derived Units

56.0K
The International System of Units or SI system, by international agreement, has fixed measurement units for seven fundamental properties: length, mass, time, temperature, electric current, amount of substance, and luminosity. These are called the SI base units.
56.0K
Resonance02:52

Resonance

66.0K
The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N-O and N=O bonds.
66.0K
The Anchoring-and-Adjustment Heuristic01:25

The Anchoring-and-Adjustment Heuristic

7.8K
In order to make good decisions, we use our knowledge and our reasoning. Often, this knowledge and reasoning is sound and solid. However, sometimes, we are swayed by biases or by others manipulating a situation. For example, let’s say you and three friends wanted to rent a house and had a combined target budget of $1,600. The realtor shows you only very run-down houses for $1,600 and then shows you a very nice house for $2,000. Might you ask each person to pay more in rent to get the...
7.8K
Adjusting a Traverse01:12

Adjusting a Traverse

389
In the site survey of a four-sided traverse, internal angles are essential to ensure geometric accuracy. The survey revealed that the sum of the measured internal angles was 359 degrees and 48 minutes, which is 12 minutes less than the expected 360 degrees. This discrepancy signals an error likely arising from measurement inaccuracies during the fieldwork.To rectify this error, the adjustment process involved distributing the 12-minute shortfall equally across the four internal angles. By...
389

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI-Powered Surface Light Microscopy for In Situ Profiling of Cell Adhesions and Membrane Protein Binding Kinetics.

Analytical chemistry·2026
Same author

Risk factors for pulmonary tuberculosis recurrence in Henan, China, from 2014 to 2024.

Scientific reports·2026
Same author

Effect of smoking on vitamin D status in the adults of Henan, China: the role of HDL-C and LDL-C.

Scientific reports·2026
Same author

Label-Free Imaging of Single Proteins and Binding Dynamics via Deep Learning-Enhanced Plasmonic Scattering Microscopy.

Journal of the American Chemical Society·2026
Same author

Standardized Protocols for Environmental Sample Collection: Minimizing Contamination and Preserving Microbial Community Integrity.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Metagenomic Data Preprocessing and Quality Control.

Methods in molecular biology (Clifton, N.J.)·2026

Related Experiment Video

Updated: Feb 11, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.8K

Surface plasmon resonance sensing with adjustable sensitivity based on a flexible liquid core coupling unit.

Jiying Xu1, Yi Chen2

  • 1Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Talanta
|April 21, 2018
PubMed
Summary

A novel liquid core coupling surface plasmon resonance (SPR) sensor offers adjustable sensitivity and broad applicability. This method enhances signal detection for applications in medical diagnostics and food safety.

Keywords:
Adjustable sensitivityCarcinoembryonic antigen (CEA)Liquid core couplingSignal amplificationSurface plasmon resonance

More Related Videos

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
07:39

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Published on: July 21, 2018

7.3K
Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
08:12

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Published on: March 13, 2013

13.2K

Related Experiment Videos

Last Updated: Feb 11, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.8K
Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
07:39

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Published on: July 21, 2018

7.3K
Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
08:12

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Published on: March 13, 2013

13.2K

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Surface plasmon resonance (SPR) sensing typically relies on sample selectivity for signal amplification.
  • Existing SPR methods often require complex sample preparation or specialized chips.

Purpose of the Study:

  • To develop a liquid core coupling SPR sensing method with adjustable sensitivity and universal applicability.
  • To demonstrate the enhanced sensitivity and practical utility of the proposed SPR sensor.

Main Methods:

  • Designed and constructed a liquid core coupling SPR sensor utilizing wavelength interrogation.
  • Adjusted sensor sensitivity by modifying the refractive index of the liquid core.
  • Validated applicability by detecting carcinoembryonic antigen (CEA) in patient samples.

Main Results:

  • Achieved a 7.8-fold enhancement in sensitivity by decreasing the liquid core refractive index.
  • Observed an 18-fold signal intensity increase for early-stage colon cancer patients compared to healthy individuals.
  • Demonstrated adequate sensitivity and simplicity, avoiding complex procedures.

Conclusions:

  • The proposed liquid core coupling SPR method offers adjustable sensitivity and universal applicability.
  • This technique shows significant promise for medical diagnostics, food safety, and environmental monitoring.
  • The method's simplicity and potential for SPR imaging extend its diagnostic capabilities.