Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

669
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
669
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

895
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
895
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.9K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K
Bacterial Transformation01:33

Bacterial Transformation

60.2K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
60.2K
Bacterial Signaling01:30

Bacterial Signaling

41.3K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
41.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ionophore PBT2 as a novel approach to combat antibiotic-resistant <i>Helicobacter pylori</i>.

mBio·2026
Same author

Norovirus-specific monoclonal antibodies that block histo-blood group antigen binding isolated from healthy donors.

Journal of virology·2026
Same author

Oxford Nanopore Technologies RNA sequencing data for investigating epigenetic regulation by phase-variable DNA methyltransferase ModD1 in serogroup B <i>Neisseria meningitidis</i>.

Microbiology resource announcements·2026
Same author

3' UTR-mediated regulation of a protein chaperone by the pspA mRNA in Streptococcus pneumoniae.

Nucleic acids research·2026
Same author

Methylome profiles to investigate gene regulation mediated by phase-variable DNA methyltransferases in serogroup B <i>Neisseria meningitidis</i>.

Microbiology resource announcements·2026
Same author

High-depth RNA-seq data to investigate gene regulation mediated by phase-variable DNA methyltransferases in serogroup B <i>Neisseria meningitidis</i>.

Microbiology resource announcements·2026

Related Experiment Video

Updated: Feb 11, 2026

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis
13:00

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis

Published on: December 11, 2012

33.5K

Glycointeractions in bacterial pathogenesis.

Jessica Poole1, Christopher J Day1, Mark von Itzstein1

  • 1Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, Australia.

Nature Reviews. Microbiology
|April 21, 2018
PubMed
Summary
This summary is machine-generated.

Bacterial pathogens use specific carbohydrate (glycan) interactions to infect hosts, influencing adhesion, invasion, and immune evasion. Advanced technologies are revealing new insights into these crucial bacterial-host glycointeractions in disease.

More Related Videos

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

8.0K
Evaluating Virulence and Pathogenesis of Aeromonas Infection in a Caenorhabditis elegans Model
06:15

Evaluating Virulence and Pathogenesis of Aeromonas Infection in a Caenorhabditis elegans Model

Published on: December 20, 2018

8.0K

Related Experiment Videos

Last Updated: Feb 11, 2026

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis
13:00

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis

Published on: December 11, 2012

33.5K
Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

8.0K
Evaluating Virulence and Pathogenesis of Aeromonas Infection in a Caenorhabditis elegans Model
06:15

Evaluating Virulence and Pathogenesis of Aeromonas Infection in a Caenorhabditis elegans Model

Published on: December 20, 2018

8.0K

Area of Science:

  • Microbiology
  • Glycoscience
  • Pathogenesis

Background:

  • Bacterial pathogenesis relies heavily on specific binding events involving host and pathogen carbohydrate structures (glycans).
  • Glycan interactions mediate critical processes like adhesion, invasion, immune evasion, and toxin receptor function.
  • Pathogens can enzymatically modify host glycans to facilitate infection or evade host defenses.

Purpose of the Study:

  • To review the role of host and bacterial glycan interactions in bacterial pathogenesis.
  • To highlight recent technological advancements in studying microbial pathogenesis glycoscience.

Main Methods:

  • Review of existing literature on bacterial-host glycointeractions.
  • Discussion of high-throughput screening technologies like lectin, glycan, and mucin microarrays.
  • Analysis of how glycan modifications by bacteria impact host-pathogen dynamics.

Main Results:

  • Identification of numerous bacterial-host glycointeractions crucial for colonization and disease.
  • Demonstration of pathogens altering host glycans to create binding sites or evade immunity.
  • Advancements in screening technologies have significantly expanded the understanding of these interactions.

Conclusions:

  • Glycan-mediated interactions are fundamental to bacterial pathogenesis.
  • Technological innovations are rapidly advancing the field of microbial glycoscience.
  • Understanding these interactions is key to developing new therapeutic strategies against bacterial infections.