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Updated: Feb 11, 2026

Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
Biotransformation of cyclocanthogenol by the endophytic fungus Alternaria eureka 1E1BL1
Güner Ekiz1, Seda Duman2, Erdal Bedir2
1Department of Pharmacognosy, Faculty of Pharmacy, Near East University, Nicosia, Mersin 10, Turkey.
Abstract:
The microbial transformation of cyclocanthogenol (CCG), Astragalus sp. originated sapogenin, by the endophytic fungus Alternaria eureka 1E1BL1 isolated from Astragalus angustifolius was investigated. Hydroxylation, oxidation, epoxidation, O-methylation, ring-expansion and methyl migration reactions were observed on the triterpenoid skeleton. As a result, eight metabolites were isolated and the structures of the previously undescribed compounds were established by 1-D, 2-D NMR and HR-MS analyses.
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