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Updated: Feb 11, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Architecture and Initial Development of a Knowledge-as-a-Service Activator for Computable Knowledge Objects for
Allen J Flynn1, Peter Boisvert2, Nate Gittlen2
1School of Information.
The Knowledge Grid (KGrid) infrastructure accelerates the application of new biomedical knowledge into practice. Its Activator component enables rapid, cloud-based deployment of computable health information for improved patient outcomes.
Area of Science:
- Biomedical informatics
- Health services research
- Computer science
Background:
- The gap between biomedical knowledge generation and clinical practice hinders effective healthcare.
- Existing infrastructure struggles to rapidly disseminate and implement new health findings.
- There is a need for scalable systems to bridge this knowledge-practice gap.
Purpose of the Study:
- To introduce the Knowledge Grid (KGrid) infrastructure.
- To describe the KGrid Activator, a core component for delivering Knowledge-as-a-Service (KaaS).
- To detail the system architecture and functions of the Activator.
Main Methods:
- Development of digital knowledge objects to represent biomedical information.
- Implementation of an online Library for storing these knowledge objects.
- Design and deployment of the Activator for on-demand KaaS delivery.
- Utilizing cloud computing for internet-scale deployment.
Main Results:
- The KGrid Activator facilitates the creation of computable biomedical knowledge.
- It enables rapid deployment of this knowledge via KaaS.
- The system architecture supports internet-scale cloud deployment for improved health applications.
Conclusions:
- The KGrid Activator is a key component for reducing the latency between knowledge discovery and practice.
- This infrastructure supports the efficient and scalable delivery of biomedical knowledge.
- The system has the potential to significantly improve healthcare through faster knowledge uptake.
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