Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Amino acids

Amino acids

Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...

Polyprotic Acids

Polyprotic Acids

Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:

Mixtures of Acids

Mixtures of Acids

The pH of a solution containing an acid can be determined using its acid dissociation constant and its initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending upon the relative strength of the acids and their dissociation constants.
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...

Nucleic Acids

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...

Nucleic acids

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...

Acidity of Carboxylic Acids

Acidity of Carboxylic Acids

Carboxylic acids are the strongest organic acids. However, their acidic strength is much less than mineral acids like HCl. Carboxylic acids ionize in water and readily lose the hydroxyl proton to form a resonance-stabilized carboxylate ion.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prevalence and Antimicrobial Susceptibility Patterns of <i>Salmonella enterica</i> Serovars Along the Dairy Value Chain: A One Health-Relevant Surveillance of Dairy Farms.

Foodborne pathogens and disease·2026

Same author

Advancing the Korpelevich method: a new approach to equilibrium problems on Hadamard manifolds.

Scientific reports·2026

Same author

ESBL and carbapenemase-producing enteric pathogens in animal-origin foods: a one health perspective.

Folia microbiologica·2026

Same author

TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins.

Autophagy reports·2026

Same author

Anti-infective potential, chemical profile, and molecular docking investigation on antioxidant-rich fraction of <i>Murraya koenigii</i> against Gram-negative pathogenic bacteria.

Frontiers in microbiology·2026

Same author

Disease modeling of myocilin mutation-dependent normal tension glaucoma: human retinal ganglion cell susceptibility to unfolded protein response and mTOR signaling.

Stem cells (Dayton, Ohio)·2026

Same journal

Preface.

Profiles of drug substances, excipients, and related methodology·2026

Same journal

Rosuvastatin calcium: A comprehensive profile.

Profiles of drug substances, excipients, and related methodology·2026

Same journal

Kinetic exclusion assay technology: Theory, experimental aspects, and applications in concentration measurements across diverse fields.

Profiles of drug substances, excipients, and related methodology·2026

Same journal

Drugs and polymer based local delivery systems in the treatment of periodontal diseases.

Profiles of drug substances, excipients, and related methodology·2026

Same journal

Perindopril: A comprehensive profile.

Profiles of drug substances, excipients, and related methodology·2026

Same journal

Ferulic acid: A comprehensive profile.

Profiles of drug substances, excipients, and related methodology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 11, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

Tolfenamic Acid.

Sofia Ahmed¹, Muhammad Ali Sheraz¹, Iqbal Ahmad¹

¹Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.

Profiles of Drug Substances, Excipients, and Related Methodology

|April 22, 2018

Summary

This summary is machine-generated.

Tolfenamic acid (TA), a nonsteroidal anti-inflammatory drug, demonstrates diverse therapeutic potential beyond pain relief. This review details analytical methods for TA assay, alongside its pharmacology and stability.

Keywords:

Analysis Dissolution Pharmacological aspects Physical properties Stability Synthesis Tolfenamic acid

More Related Videos

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores

Published on: August 19, 2013

Establishment of an Extracellular Acidic pH Culture System

Establishment of an Extracellular Acidic pH Culture System

Published on: November 19, 2017

Related Experiment Videos

Last Updated: Feb 11, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores

Published on: August 19, 2013

Establishment of an Extracellular Acidic pH Culture System

Establishment of an Extracellular Acidic pH Culture System

Published on: November 19, 2017

Area of Science:

Pharmacology
Analytical Chemistry
Medicinal Chemistry

Background:

Tolfenamic acid (TA) is a nonsteroidal anti-inflammatory drug (NSAID) from the fenamate class.
It is clinically utilized for acute migraine, dysmenorrhea, rheumatoid arthritis, and osteoarthritis.
Emerging research highlights TA's potential in antibacterial applications, Alzheimer's disease, and oncology.

Purpose of the Study:

To comprehensively review the physical and pharmaceutical properties of Tolfenamic acid.
To detail various analytical methods for assaying TA in pharmaceutical and biological matrices.
To discuss TA's stability, degradation, pharmacology, pharmacokinetics, and clinical use.

Main Methods:

Review of identification tests, titrimetric, spectrophotometric, chromatographic, electrochemical, thermal, microscopic, enzymatic, and solid-state analytical techniques.
Analysis of literature concerning TA's stability, degradation pathways, and pharmacokinetic profiles.
Compilation of data on dosage forms, adverse effects, toxicity, and drug interactions.

Main Results:

TA exhibits broad-spectrum analytical methodologies for its quantification.
The drug displays significant in vitro antibacterial activity when complexed with bismuth(III).
TA shows promise as an anticancer agent and in mitigating Alzheimer's disease pathology.

Conclusions:

A thorough understanding of TA's analytical, physicochemical, and pharmacological properties is crucial for its effective clinical application.
The diverse applications of TA warrant continued investigation into its therapeutic potential and analytical characterization.
This review provides a consolidated resource for researchers and clinicians working with Tolfenamic acid.