Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

962
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
962
Stages of Sleep01:22

Stages of Sleep

1.5K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.5K
Understanding Sleep01:11

Understanding Sleep

1.6K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.6K
Sleep Apnea01:21

Sleep Apnea

591
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
591
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

950
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
950

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder.

NPJ Parkinson's disease·2026
Same author

Presynaptic dopaminergic imaging as a neurodegeneration staging biomarker in the alpha-synucleinopathy continuum.

European journal of nuclear medicine and molecular imaging·2026
Same author

Obesity is linked to impaired sensorimotor synchronization during walking but not tapping.

Scientific reports·2026
Same author

Shared Pathogenic Pathways Between REM Sleep Behavior Disorder and Neurodegenerative and Psychiatric Disorders.

medRxiv : the preprint server for health sciences·2026
Same author

Lack of epistatic interaction of <i>SNCA</i> with <i>APOE</i> in synucleinopathies.

Brain communications·2025
Same author

Post-traumatic stress disorder and REM-sleep behavior disorder: exploring genetic associations and causal links.

medRxiv : the preprint server for health sciences·2025
Same journal

Visual Impairment and Driving in Older Adults: A Narrative Review.

Current treatment options in neurology·2026
Same journal

Non-Cognitive Symptoms in Alzheimer's Disease and Their Likely Impact on Patient Outcomes. A Scoping Review.

Current treatment options in neurology·2026
Same journal

Update on the Treatment of Autonomic Disorders.

Current treatment options in neurology·2025
Same journal

Primary Progressive Aphasia Treatment: Current Treatment Options in Neurology Article Topic: Management of Primary Progressive Aphasia.

Current treatment options in neurology·2025
Same journal

Emerging Principles for Treating Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD).

Current treatment options in neurology·2025
Same journal

Diagnosis and Management of Progressive Corticobasal Syndrome.

Current treatment options in neurology·2025
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Quantitative Measurement of the Immune Response and Sleep in Drosophila
12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

16.0K

Sleep Abnormalities in MultipleSystem Atrophy.

Valérie Cochen De Cock1,2

  • 1Pôle sommeil et neurologie, Clinique Beau Soleil, 119 avenue de Lodève, 34070, Montpellier, France. valerie.cochen@gmail.com.

Current Treatment Options in Neurology
|April 22, 2018
PubMed
Summary
This summary is machine-generated.

Multiple System Atrophy (MSA) is linked to severe sleep disorders like insomnia and REM sleep behavior disorder (RBD). Stridor indicates a poor prognosis, but treatments like CPAP and tracheostomy can be effective.

Keywords:
Central sleep apnea syndromeInsomniaMultiple system atrophyObstructive sleep apnea syndromePeriodic limb movementsREM sleep behavior disorderRestless legs syndromeSleepinessStridor

More Related Videos

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

25.3K
The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

4.2K

Related Experiment Videos

Last Updated: Feb 11, 2026

Quantitative Measurement of the Immune Response and Sleep in Drosophila
12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

16.0K
Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

25.3K
The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

4.2K

Area of Science:

  • Neurology
  • Sleep Medicine

Background:

  • Multiple System Atrophy (MSA) is a neurodegenerative disorder.
  • Sleep disorders are common and significantly impact patient quality of life.

Purpose of the Study:

  • To review sleep disorders associated with MSA.
  • To explore their underlying mechanisms.
  • To discuss current treatment options.

Main Methods:

  • Literature review of studies on MSA and sleep disorders.
  • Analysis of mechanisms including neurological pathways and treatment side effects.
  • Evaluation of treatment efficacy for specific sleep disorders.

Main Results:

  • Stridor is a critical diagnostic sign in early MSA, correlating with reduced life expectancy.
  • Effective management of stridor includes continuous positive airway pressure (CPAP) or tracheostomy.
  • Common sleep disorders in MSA include insomnia, daytime sleepiness, restless legs syndrome (RLS), REM sleep behavior disorder (RBD), and sleep-disordered breathing (SDB).
  • REM sleep behavior disorder (RBD) is highly prevalent at the onset of motor symptoms.

Conclusions:

  • Sleep disorders are frequent and severe in MSA, stemming from complex neurological and symptomatic factors.
  • Prompt management of stridor is crucial for improving outcomes in MSA patients.
  • Targeted treatments for sleep disorders can alleviate symptoms and improve quality of life in individuals with MSA.